After maturation, in primary lymphoid organs, the lymphocytes migrate for interaction with antigens to secondary lymphoid organ(s)/tissue(s) like:
A. thymus
B. bone marrow
C. spleen
D. lymph nodes
E. Peyer's patches
Choose the correct answer from the options given below:  

The correct answer is C, D, E only

Concept:

• Lymphoid organs are the organs where the origin and/or maturation and proliferation of lymphocytes occur.
• The primary lymphoid organs are bone marrow and thymus, where immature lymphocytes differentiate into antigen-sensitive lymphocytes.
• After maturation, the lymphocytes migrate to secondary lymphoid organs like the spleen, lymph nodes, tonsils, Peyer’s patches of small intestine, and appendix.
• The secondary lymphoid organs provide the sites for interaction of lymphocytes with the antigen, which then proliferate to become effector cells.

Explanation:

• Spleen (C): The spleen filters blood and is a site where lymphocytes interact with blood-borne antigens. It plays a crucial role in immune responses to pathogens circulating in the bloodstream.
• Lymph Nodes (D): Lymph nodes are distributed throughout the body and filter lymph. They trap antigens from lymphatic fluid and allow interaction between lymphocytes and antigens, activating adaptive immune responses.
• Peyer’s Patches (E): Peyer’s patches are specialized mucosa-associated lymphoid tissues in the small intestine. They monitor intestinal contents for antigens and are essential for immune responses in the gut-associated lymphoid tissue (GALT).

Incorrect Options:

• Thymus (A): The thymus is a primary lymphoid organ responsible for the maturation of T cells. 
• Bone Marrow (B): The bone marrow is another primary lymphoid organ responsible for the development and maturation of B cells.