Threshold dose is the:

The correct answer is - Highest dose at which no toxic effect occurs

Key Points

• Threshold dose
  • The threshold dose is the highest dose at which no toxic effect occurs.
  • It is important to differentiate it from the lowest dose at which no toxic effect occurs, which is often referred to as the no observed adverse effect level (NOAEL).
  • Understanding the threshold dose helps in determining safe exposure levels for chemicals and substances.

Additional Information

• Related Concepts in Toxicology
  • NOAEL (No Observed Adverse Effect Level)
    • This is the highest dose at which there are no observed adverse effects in exposed subjects.
    • NOAEL is used in risk assessment to set exposure limits for humans.
  • LOAEL (Lowest Observed Adverse Effect Level)
    • This is the lowest dose at which adverse effects are observed in exposed subjects.
    • LOAEL helps in understanding the dose-response relationship and is also used in risk assessments.
  • Lethal Dose (LD50)
    • The dose which is lethal to 50% of the exposed population.
    • It is a common measure used to assess the toxicity of a substance.