Drugs which are having high solubility and low permeability are called as

Question

Question

This question was previously asked in

RRB Pharmacist Exam Paper 2019

Answer 1

Correct Answer: Class III drugs

Rationale:

The Biopharmaceutics Classification System (BCS) classifies drugs based on their solubility and permeability.
Class III drugs are characterized by high solubility and low permeability. This means that while the drug can dissolve easily in the gastrointestinal fluids, its absorption through the intestinal wall is limited.
High solubility indicates that a drug dissolves readily in the gastrointestinal tract, but low permeability suggests that the drug does not pass easily through the cell membranes lining the gut into the bloodstream.

Explanation of Other Options:

Class IV drugs

Rationale: Class IV drugs have low solubility and low permeability. These drugs pose significant challenges in drug delivery and absorption.

Class I drugs

Rationale: Class I drugs have high solubility and high permeability. They are typically well-absorbed and pose fewer challenges in terms of bioavailability.

Class II drugs

Rationale: Class II drugs have low solubility and high permeability. While they can permeate the gut wall effectively, their low solubility can be a limiting factor in their overall absorption.

Conclusion:

Class III drugs, characterized by high solubility and low permeability, fit the description given in the question. This classification helps in understanding the challenges related to the drug’s absorption and bioavailability.
The other classes, including Class I (high solubility, high permeability), Class II (low solubility, high permeability), and Class IV (low solubility, low permeability), do not match the given characteristics.